硕士生导师

张占辉

发布时间:2015-03-10   浏览次数:0

张占辉,男,1965年生于河北省深泽县,研究员,专业技术三级,有机化学专业博士生导师,2006年于南开大学有机化学专业取得博士学位 (导师:王永梅教授),河北省三三三人才工程人选,河北省优秀教师。已在SCI收录的期刊上发表论文110多篇,论文在SCI数据库中被引用5000多次 (ResearchIDH-1558-2011h-index: 47),先后有5篇论文作为高被引论文入选ESI数据库。主持完成国家自然科学基金项目三项,河北省自然科学基金项目三项。获河北省自然科学一等奖一项、三等奖两项、科技进步三等奖一项,批准临床新药1个。担任《Arkivoc》、《Current Organocatalysis》和《煤炭与化工》杂志编委,50多种SCI期刊审稿人,获2018年度“Publons同行评议奖”。

已指导15届研究生,其中毕业36人,在学7人。指导的研究生有9人获国家奖学金,6人获河北师范大学华藏奖学金,5人毕业论文获河北省优秀硕士学位论文。指导的本科生科技创新课题在第11121415挑战杯全国大学生课外学术科技作品竞赛中获奖。

从事的学科专业为有机化学,主要研究方向为原料药、医药中间体、精细化学品的合成及有机合成反应方法学等。

办公室:理科群7号楼A403

科研室:理科群7号楼B503B505B507

E-mail: zhanhui@ hebtu.edu.cn;zhanhui@126.com

一、主持的部分科研课题:

1. 国家自然科学基金

(1)新型烷()氧羰基异氰酸酯的合成及其在有机合成中的应用 (20872025).

(2)新型环状过氧化物的合成方法研究 (21072042).

(3)新型功能化磁性纳米催化剂的设计及在杂环化合物合成中的应用 (21272053).

2. 河北省自然科学基金

(1) 环尿素合成新方法的研究 (B2008000149).

(2) 磁性纳米材料催化的多组分一锅反应研究(B2011205031).

(3) 低共熔溶剂中多组分反应合成含氮杂环化合物(B2015205182).

二、科研获奖

1.张占辉、默丽萍、李培贺、王宏娟. C-NC-O键的构建及含N杂环化合物的绿色合成方法研究,河北省自然科学一等奖,2016.

2.张占辉、默丽萍、刘玉衡、胡进勇. N杂环及β-羟基和氨基类化合物绿色合成方法研究,河北省自然科学三等奖,2012.

3.刘庆彬、马杰、张占辉、房桂珍、康丽娟、张丽芳、张福军、薄海静. 薁磺酸钠原料药和复方谷氨酰胺颗粒的研制,河北省科技进步三等奖,2009.

三、发表的论文:

发表论文见:http://www.researcherid.com/rid/H-1558-2011

论文全文见:https://www.researchgate.net/profile/Zhan-Hui_Zhang/contributions

https://www.scholarmate.com/psnweb/homepage/show?module=pub

近期部分论文如下:

(1)Han, Y.; Zhang, M.; Zhang, Y. Q.; Zhang, Z.H.* Copper immobilized at a covalent organic framework: An efficient andrecyclable heterogeneous catalyst for the Chan-Lam coupling reaction of arylboronic acids and amines. Green Chem.2018, 20, 4891-4900.

(2)Zhang, M.; Han, Y.; Niu, J.L.; Zhang, Z. H.* A general and practicalapproach for the synthesis of 1,2,4-trioxanes catalyzed by silica-ferricchloride. Adv. Synth. Catal.2017, 359, 3618-3625.

(3)Zhang, M.; Fu, Q. Y.; Gao, G.; He, H. Y.;Zhang, Y.; Wu, Y. S.*; Zhang, Z. H.* Catalyst-free, visible-light promoted one-potsynthesis of spirooxindole-pyran derivatives in aqueous ethyl lactate. ACS Sustainable Chem. Eng. 2017,5, 6175-6182.

(4)Ma, C.-T.; Liu, P.; Wu, W.; Zhang, Z. H.*Low melting oxalic acid/proline mixture as dual solvent/catalyst for efficientsynthesis of 13-aryl-13H-benzo[g]benzothiazolo[2,3-b]buinazoline-5,4-diones under microwave irradiation. J. Mol. Liq. 2017,242, 606-611.

(5)Zhang, M.; Liu, Y. H.; Shang, Z. R.; Hu, H.C.; Zhang, Z. H.* Supported molybdenum on graphene oxide/Fe3O4:An efficient, magnetically separable catalyst for one-pot construction ofspiro-oxindole dihydropyridines in deep eutectic solvent under microwaveirradiation. Catal. Commun. 2017,88, 39-44.

(6)Zhang, J. N.; Yang, X. H.; Guo, W. J.; Wang,B.; Zhang, Z. H.* Magnetic Metal-Organic Framework CoFe2O4@SiO2@IRMOF-3as an efficient catalyst for one-pot synthesis of functionalizeddihydro-2-oxopyrroles. Synlett 2017,28, 734-740.

(7)Zhang, H. Y.; Hao, X. P.; Mo, L. P.; Liu, S.S.; Zhang, W. B.; Zhang, Z. H.* A magnetic metal-organic framework as a highlyactive heterogeneous catalyst for one-pot synthesis of 2-substituted alkyl andaryl(indolyl)kojic acid derivatives. NewJ. Chem. 2017,41, 7108-7115.

(8)Zhang, M.; Lu, J.; Zhang, J. N.; Zhang, Z.H.* Magnetic carbon nanotube supported Cu (CoFe2O4/CNT-Cu)catalyst: A sustainable catalyst for the synthesis of3-nitro-2-arylimidazo[1,2-a]pyridines.Catal. Commun. 2016,78, 26-32.

(9)Hu, G. F.; Cheng, H. B.;* Niu, J. L.; Zhang,Z. H.;* Wu, H. C. A multi-responsive molecular switch based on a diarylethenederivative containing dinitrobenzenesulfonic amide groups. Dyes Pigm. 2017,136, 354-360.

(10)Zhang, M.; Liu, P.; Liu, Y. H.; Shang, Z.R.; Hu, H. C.; Zhang, Z. H.* Magnetically separable graphene oxide anchoredsulfonic acid: a novel, highly efficient and recyclable catalyst for one-potsynthesis of 3,6-di(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles in deepeutectic solvent under microwave irradiation. RSC Adv. 2016,6, 106160-106170.

(11)Liu, P.; Hao, J. W.; Zhang, Z. H.* AGeneral, efficient and green procedure for synthesis ofdihydropyrimidine-5-carboxamides in low melting betaine hydrochloride/ureamixture. Chin. J. Chem. 2016,34, 637-645.

(12)Lu, J.; Ma, E. Q.; Liu, Y. H.; Li, Y. M.;Mo, L. P.; Zhang, Z. H.* One-pot three-component synthesis of 1,2,3-triazolesusing magnetic NiFe2O4-glutamate-Cu as an efficientheterogeneous catalyst in water. RSC Adv.2015,5, 59167-59185.

(13)Liu, P.; Hao, J. W.; Mo, L. P.; Zhang, Z.H.* Recent advances in the application of deep eutectic solvents as sustainablemedia as well as catalysts in organic reactions. RSC Adv. 2015,5, 48675-48704.

(14)Li, X. T.; Liu, Y. H.; Liu, X.; Zhang, Z.H.* Meglumine catalyzed one-pot, three-component combinatorial synthesis ofpyrazoles bearing a coumarin unit. RSCAdv. 2015,5, 25625-25633.

(15)Hu, H. C.; Liu, Y. H.; Li, B. L.; Cui, Z.S.; Zhang, Z. H.* Deep eutectic solvent based on choline chloride and malonicacid as an efficient and reusable catalytic system for one-pot synthesis offunctionalized pyrroles. RSC Adv. 2015,5, 7720-7728.

(16)Zhao, X. N.; Hu, H. C.; Zhang, F. J.; Zhang,Z. H.* Magnetic CoFe2O4 nanoparticle immobilized N-propyldiethylenetriamine sulfamic acid as an efficient and recyclable catalyst forthe synthesis of amides via the Ritter reaction. Appl. Catal. A: Gen. 2014,482, 258-265.

(17)Zhao, X. N.; Hu, G. F.; Tang, M.; Shi, T.T.; Guo, X. L.; Li, T. T.; Zhang, Z. H.* A highly efficient and recyclablecobalt ferrite chitosan sulfonic acid magnetic nanoparticle for one-pot,four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones.RSC Adv. 2014,4, 51089-51097.

(18)Wang, P.; Ma, F. P.; Zhang, Z. H.* l-(+)-Tartaric acid and choline chloridebased deep eutectic solvent: An efficient and reusable medium for synthesis of N-substituted pyrroles via Clauson-Kaasreaction. J. Mol. Liq. 2014,198, 259-262.

(19)Lu, J.; Li, X. T.; Ma, E. Q.; Mo, L. P.;Zhang, Z. H.* Superparamagnetic CuFeO2 nanoparticles in deepeutectic solvent: an efficient and recyclable catalytic system for thesynthesis of imidazo[1,2-a]pyridines.ChemCatChem 2014,6, 2854-2859.

(20)Li, X. T.; Zhao, A. D.; Mo, L. P.; Zhang, Z.H.* Meglumine catalyzed expeditious four-component domino protocol forsynthesis of pyrazolopyranopyrimidines in aqueous medium. RSC Adv. 2014,4, 51580-51588.

(21)Li, P. H.; Li, B. L.; Hu, H. C.; Zhao, X.N.; Zhang, Z. H.* Ionic liquid supported on magnetic nanoparticles as highlyefficient and recyclable catalyst for the synthesis of b-keto enol ethers. Catal. Commun. 2014,46, 118-122.

(22)Li, B. L.; Zhang, M.; Hu, H. C.; Du, X.;Zhang, Z. H.* Nano-CoFe2O4 supported molybdenum as anefficient and magnetically recoverable catalyst for a one-pot, four-componentsynthesis of functionalized pyrroles. NewJ. Chem. 2014,38, 2435-244.

(23)Li, B. L.; Hu, H. C.; Mo, L. P.; Zhang, Z.H.* Nano CoFe2O4 supported antimony(III) as an efficientand recyclable catalyst for one-pot three-component synthesis ofmultisubstituted pyrroles. RSC Adv. 2014,4, 12929-12943.

(24)Ma, F. P.; Li, P. H.; Li, B. L.; Mo, L. P.;Liu, N.; Kang, H. J.; Liu, Y. N.; Zhang, Z. H.* A recyclable magneticnanoparticles supported antimony catalyst for the synthesis of N-substituted pyrroles in water. Appl. Catal. A: Gen. 2013,457, 34-41.

(25)Li, P. H.; Li, B. L.; An, Z. M.; Mo, L. P.;Cui, Z. S.; Zhang, Z. H.* Magnetic nanoparticles (CoFe2O4)-SupportedPhosphomolybdate as an efficient, green, recyclable catalyst for synthesis of b-hydroxyhydroperoxides. Adv. Synth. Catal. 2013,355, 2952-2959.

(26)Li, B. L.; Li, P. H.; Fang, X. N.; Li, C.X.; Sun, J. L.; Mo, L. P.; Zhang, Z. H.* One-pot four-component synthesis ofhighly substituted pyrroles in gluconic acid aqueous solution. Tetrahedron 2013,69, 7011-7018.

(27)Guo, R. Y.; Wang, P.; Wang, G. D.; Mo, L.P.; Zhang, Z. H.* One-pot three-component synthesis of functionalizedspirooxindoles in gluconic acid aqueous solution. Tetrahedron 2013,69, 2056-2061.

(28)Guo, R. Y.; An, Z. M.; Mo, L. P.; Yang, S.T.; Liu, H. X.; Wang, S. X.; Zhang, Z. H.* Meglumine promoted one-pot,four-component synthesis of pyranopyrazole derivatives. Tetrahedron 2013,69, 9931-9938.

(29)Guo, R. Y.; An, Z. M.; Mo, L. P.; Wang, R.Z.; Liu, H. X.; Wang, S. X.; Zhang, Z. H.* Meglumine: a novel and efficientcatalyst for one-pot, three-component combinatorial synthesis of functionalized2-amino-4H-pyrans. ACS Comb. Sci. 2013,15, 557-563.

(30)Zhang, Z. H.; Zhang, X. N.; Mo, L. P.; Li,Y. X.; Ma, F. P., Catalyst-free synthesis of quinazoline derivatives using lowmelting sugar-urea-salt mixture as a solvent. Green Chem. 2012,14, 1502-1506.

(31)Liu, Y. H.; Deng, J.; Gao, J. W.; Zhang, Z.H.* Triflic acid-functionalized silica-coated magnetic nanoparticles as amagnetically separable catalyst for synthesis of gem-dihydroperoxides. Adv. Synth. Catal. 2012,354, 441-447.

(32)Deng, J.; Mo, L. P.; Zhao, F. Y.; Zhang, Z.H.; Liu, S. X., One-pot, three-component synthesis of a library ofspirooxindole-pyrimidines catalyzed by magnetic nanoparticle supported dodecylbenzenesulfonic acid in aqueous media. ACSComb. Sci. 2012,14, 335-341.

(33)Zhang, X. N.; Li, Y. X.; Zhang, Z. H.*Nickel chloride-catalyzed one-pot three-component synthesis ofpyrazolophthalazinyl spirooxindoles. Tetrahedron2011,67, 7426-7430.

(34)Wang, H. J.; Mo, L. P.; Zhang, Z. H.* Ceriumammonium nitrate-catalyzed multicomponent reaction for efficient synthesis offunctionalized tetrahydropyridines. ACSComb. Sci. 2011,13, 181-185.

(35)Mo, L. P.; Zhang, Z. H.* Recent applicationsof zirconium compounds as catalysts or reagents in organic synthesis. Curr. Org. Chem. 2011,15, 3800-3823.

(36)Deng, J.; Mo, L. P.; Zhao, F. Y.; Hou, L.L.; Yang, L.; Zhang, Z. H.* Sulfonic acid supported onhydroxyapatite-encapsulated-g-Fe2O3 nanocrystallites as amagnetically separable catalyst for one-pot reductive amination of carbonylcompounds. Green Chem. 2011,13, 2576-2584.

(37)Zhang, Z. H.; Lu, H. Y.; Yang, S. H.; Gao,J. W., synthesis of 2,3-dihydroquinazolin-4(1H)-ones by three-component coupling of isatoic anhydride, amines,and aldehydes catalyzed by magnetic Fe3O4 nanoparticlesin water. J. Comb. Chem. 2010,12, 643-646.

四、获奖学生名单

1. 河北师范大学研究生华藏奖学金

李键煚 (2007)、刘玉衡 (2009)、王宏娟 (2010)、侯俊涛 (2011)、邓佳 (2012)、马飞平(2013)

2. 河北省优秀硕士学位论文

刘玉衡 (2010)、吕红艳 (2011)、侯俊涛(2012)、邓佳(2013)、李培贺(2015)

3. 研究生国家奖学金

李永肖、郭瑞云 (2012)、李培贺 (2013)、芦军、赵晓娜、胡海船 (2014)、李晓堂 (2015)、刘鹏 (2016)、韩旖 (2018)

4. 大学生课外学术科技作品竞赛

(1)刘秋双. β-氨基醇的新合成方法研究. 第十一届挑战杯全国大学生课外学术科技作品竞赛三等奖,2009, 北京.

(2)孙国英、芦军、孙文博. 多组分一锅法合成氨基磷酸酯和四氢苯并吡喃化合物. 第十二届挑战杯全国大学生课外学术科技作品竞赛二等奖,2011, 大连.

(3)刘红霞、张默、唐蒙. N杂环化合物的绿色合成方法研究. 第十四届挑战杯全国大学生课外学术科技作品竞赛三等奖,2015, 广州; 2015年河北省挑战杯课外学术科技作品竞赛特等奖.

(4)刘红霞、王书霞. 葡甲胺催化合成吡喃并吡唑衍生物. 第八届全国大学生创新创业年会, 2015, 哈尔滨.

(5)尚泽仁、李欣然、杨秀欢. 功能有机中间体的绿色合成方法研究. 河北省挑战杯课外学术科技作品竞赛特等奖, 2017, 石家庄;第十五届挑战杯全国大学生课外学术科技作品竞赛三等奖,2017, 上海.

(6)郭伟杰、王博、杨秀欢. 新型磁性催化剂催化合成二氢吡咯衍生物. 第三届河北省大学生创新创业年会一等奖, 2018, 秦皇岛.

五、荣誉称号

2009年入选河北省三三三人才工程第三层次

2010年获河北省优秀硕士论文指导教师

2011年获河北省优秀硕士论文指导教师

2012年获河北师范大学校级优秀共产党员

2012年获河北师范大学大学生课外学术科技创新活动优秀指导教师

2013年获河北省优秀硕士论文指导教师

2014年获河北省优秀硕士论文指导教师

2015年获河北省大学生“挑战杯”科技作品优秀指导教师

2015年获河北师范大学优秀研究生指导教师

2016年获河北师范大学教书育人模范教师

2017年获河北省优秀教师

2017年获河北省大学生“挑战杯”科技作品优秀指导教师

2017年获河北师范大学专业综合实习优秀指导教师

2017年获河北师范大学处级先进工作者